Issued2026-01-14

Guiding Principles for Good AI Practice in Drug Development

Final GuidanceSector

Summary

Joint EMA-FDA principles describing how artificial intelligence and machine learning can be responsibly integrated across the lifecycle of medicinal product development, including discovery, trial design, data management, analysis, and post-authorization activities.

Healthcare Implications

Signals regulators’ expectations for safe, transparent, and robust use of AI in drug development workflows; encourages sponsors to build governance, validation, and monitoring processes that protect patients, improve evidence quality, and reduce bias in AI-enabled trials and decision making.

Impact Level

Medium

Keywords

Safety & Risk; Clinical Quality & Efficacy; Transparency & Governance; Privacy & Data

Stakeholders

Developers & Vendors; Regulators & Government; Providers & Health Systems