Issued2025-04-03

OMB Memorandum M-25-21 – Accelerating Federal Use of AI through Innovation, Governance, and Public Trust

MemorandumFederal

Summary

Government-wide OMB memo that rescinds M-24-10 and establishes new requirements for how federal agencies identify, govern, and expand their use of AI, including inventories of AI use cases, risk assessment processes, governance structures, and public reporting.

Healthcare Implications

Requires HHS, CMS, NIH, CDC, VA, and other health-related agencies to maintain AI use inventories, implement AI risk management and governance processes, and safeguard civil rights, privacy, and safety when using AI in clinical programs, public health surveillance, and health benefits administration.

Impact Level

High

Keywords

Safety & Risk; Privacy & Data; Transparency & Governance; Equity & Bias

Stakeholders

Regulators & Government; Providers & Health Systems; Developers & Vendors; Patients & Public