Issued2025-08-18

Marketing Submission Recommendations for a Predetermined Change Control Plan for Artificial Intelligence-Enabled Device Software Functions

Final GuidanceSector

Summary

Provides FDA recommendations for predetermined change control plans in marketing submissions for AI-enabled devices, including planned modifications, methods to develop, validate, and implement them, and an assessment of their impact.

Healthcare Implications

Allows developers to seek authorization for specified postmarket model changes without a new marketing submission for each change, while establishing clearer expectations for validation, labeling, change control, and continued device safety and effectiveness.

Impact Level

Medium

Keywords

Transparency & Governance; Safety & Risk; Clinical Quality & Efficacy

Stakeholders

Developers & Vendors; Providers & Health Systems; Patients & Public; Regulators & Government