Issued2025-01-29

Good Machine Learning Practice for Medical Device Development: Guiding Principles

GuidanceVoluntary

Summary

Final IMDRF guiding principles for good machine learning practice in medical device development. The document identifies high-level principles for developing, validating, monitoring, and managing machine-learning-enabled medical devices across the product lifecycle, building on earlier FDA, Health Canada, and MHRA GMLP principles.

Healthcare Implications

Provides medical-device developers, regulators, and health systems with a globally harmonized reference for AI/ML device quality, data management, model development, evaluation, monitoring, and lifecycle governance. It supports safer and more consistent development of AI-enabled medical devices used in diagnosis, monitoring, treatment support, and clinical workflow.

Impact Level

Low

Keywords

Safety & Risk; Clinical Quality & Efficacy; Transparency & Governance

Stakeholders

Developers & Vendors; Regulators & Government; Providers & Health Systems; Patients & Public