Issued2025-12-24

Best Practice Guide and Testing & Evaluation Framework for AI-Enabled Clinical Decision Support

Best Practice Guide / Testing & Evaluation FrameworkVoluntary

Summary

Provides consensus practices and evaluation methods for AI-enabled clinical decision support, with a focus on large-language-model and retrieval-augmented systems that deliver evidence-based medical information at the point of care, including evidence concordance, citation accuracy, usability, safety, and transparency.

Healthcare Implications

Developers and health systems should validate outputs against specialty guidelines and reference evidence, verify citations, measure hallucinations and clinically significant errors, preserve clinician responsibility, test workflow usability, and monitor performance and safety after deployment.

Impact Level

Medium

Keywords

Clinical Quality & Efficacy; Safety & Risk; Transparency & Governance; Equity & Bias

Stakeholders

Providers & Health Systems; Patients & Public; Developers & Vendors; Regulators & Government