Issued2025-09-10

ANSI/CTA-2135 – Performance Verification and Validation for Predictive Health AI Solutions

StandardVoluntary

Summary

Voluntary standard establishing methodology for pre-market verification and validation of predictive health AI solutions. The standard focuses on non-generative predictive AI and addresses data verification, accuracy and reliability measurement, explainability, usability, model management, external validation, and real-world operational validation before deployment.

Healthcare Implications

Provides developers and health technology vendors with a concrete validation framework for predictive health AI tools before they enter real-world healthcare use. Health systems, payers, and regulators can use the standard as a reference point when evaluating vendor evidence for accuracy, data quality, demographic representativeness, explainability, model drift planning, and real-world performance in clinical or administrative workflows.

Impact Level

Medium

Keywords

Safety & Risk; Clinical Quality & Efficacy; Transparency & Governance; Equity & Bias

Stakeholders

Developers & Vendors; Providers & Health Systems; Payers & Purchasers; Regulators & Government